Bosh paced the Heat with 30 points, and James added 28 of his own to go along with 9 rebounds and 5 assists.
G Lou Williams came off the bench to score 22 points for the 76ers, but Philadlephia ran out of gas in their third game in four nights.
Despite the loss, the 76ers remain four and a half games ahead of the New York Knicks in the Atlantic Division, but fall behind Miami in the overall Eastern Conference standings.
Both teams shot the ball well on Saturday night, but strong quarters to end each of the halves proved to be the difference in Miami's win.
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