Leading the way was James Harden, who scored 33 points in the win for the Rockets. Accounting for most of that was his 17-for-18 shooting from the free throw line.
Helping Harden carry the load was Omer Asik. The big man finished with 17 points and 15 rebounds. Toney Douglas came off the bench to add 17 points, as well.
In the defeat, Nick Young had 21 points for Philadelphia, while Dorell Wright contributed 20 points.
The win is the fourth in five games for the Rockets. They will look to continue their momentum on Saturday on the road against the Memphis Grizzlies.
Meanwhile, the Sixers have lost five straight games and eight of their last 10. They will try to get headed back in the other direction at home against the Atlanta Hawks on Friday.