Andre Iguodala added 16 points and seven rebounds and Lou Williams scored 11 of his 15 points in a final quarter that saw Philadelphia shoot 15-of-19 from the field.
Elton Brand posted a double-double with 14 points and 10 rebounds, as the Sixers won for just the second time in their last 10 games.
Brook Lopez and Devin Harris netted 25 and 19 points, respectively, for the Nets, who have lost five of their last six -- all on the road.
The Sixers broke open a 66-all tie with a 10-2 run to start the final stanza. Thaddeus Young scored seven of his 13 points during the spurt, and Iguodala ended it with a three-pointer for a 76-68 advantage with nine minutes to go.
Lopez's bucket cut the margin to 78-74 near the seven-minute mark, but a Williams four-point play sparked a 12-2 flurry for the hosts. Tony Battie's jumper provided a 90-76 cushion with 4 1/2 minutes to go, and it was a double- digit contest the rest of the way.
The Nets trailed 27-24 after the first quarter but used an 11-point run midway through the second to take the lead, 41-39, on a Harris three-pointer with 4 1/2 minutes left. New Jersey maintained a 48-46 lead at halftime.
Philadelphia took all four meetings from its Atlantic Division rival a season ago...The Sixers shot 51.2 percent overall, compared to 40.7 percent for the Nets...Kris Humphries pulled down a game-high 15 rebounds for New Jersey...Holiday tied his career high for assists.