Corey Stokes added 19 points, including five three-pointers, and Mouphtaou Yarou scored 14 for the Wildcats (10-1), who have won five straight and will next face Big 5 rival Temple on December 30.
Maalik Wayns had 11 points and six assists for the victors.
The Wildcats jumped out to an early lead and never looked back.
Monmouth's R.J. Rutledge made the first of two foul shots to tie the game at 5-5 with 16:08 remaining in the first half, but Fisher's jumper on the other end started a 19-2 run for Villanova that put the game away for good.
Stokes followed Fisher's jumper with a layup in the lane, and Fisher added two more jump shots -- surrounding a Davis layup -- to put Villanova up 13-7.
The Wildcats scored a total of 13 unanswered points and the Hawks went 0-for-6 from the field to widen Villanova's lead to 24-7 with 8:32 left in the half.
Fisher and Stokes scored 13 and 11 points, respectively, for Villanova in the first half, en route to a 44-17 lead at the break.
Monmouth would never threaten down the stretch.
Villanova shot 50 percent from the field, while Monmouth shot just 25.5 percent...The Wildcats converted 13 turnovers into 23 points...The Hawks shot 1-for-19 from beyond the arc.