Dorell Wright and Jrue Holiday also made significant contributions on the offensive end for the Sixers, scoring 17 and 13, respectively.
Down two points in the second quarter, Philly essentially put this game out of reach before halftime, as they went on a 21-2 run to take a commanding 51-30 lead.
Kyrie Irving led the Cavaliers with 23 points, while Tristan Thompson had 10 points and 10 rebounds. The Cavaliers scored just three points through the first eight minutes of the second quarter.
Rookie Dion Waiters struggled, scoring just five points on 2-9 shooting for Cleveland.
The Sixers were sharp from beyond the arc, hitting 12 of 25 three-pointers.
Newly acquired center Andrew Bynum did not play for Philadelphia, as he continues to sit out the pre-season while recovering from off-season knee treatment.