Andy Reid's group will have a different feel after last week's bye, with Todd Bowles replacing the fired Juan Castillo as defensive coordinator. The Eagles have struggled to a 3-3 record thus far, with another major problem being Michael Vick's proneness to turnovers.
There has already been ample speculation that the Eagles could pull Vick in favor of rookie quarterback Nick Foles if the issues continue for a Philadelphia team with high expectations.
Another game with big implications is the NFC East clash between the New York Giants and Dallas Cowboys. Tony Romo led Dallas to a 24-17 win over Big Blue in the season opener and now goes for the sweep.