The Cardinals opened the scoring with a 47-yard field goal by Jay Feely that capped their first drive of the game.
After forcing a second punt from the Eagles, Arizona scored the game's first touchdown on a pass from Kevin Kolb to rookie Michael Floyd. The eight-yard touchdown pass and ensuing extra point by Feely, put the Cardinals ahead, 10-0.
Arizona's defense dominated the first quarter. The Eagles only ran 11 plays in the first quarter, gaining 61 yards. Arizona's offense had scoring drives of 36 and 38 yards in the first quarter as the hosts took the early lead.