Penn State, who earned their first win of the season last week will take on Temple, who looks to stay above .500 in a battle of schools with Philadelphia ties.
The Nittany Lions are 1-2 after beating Navy 34-17 and have improved each week under new coach Bill O'Brien. The Owls suffered their first loss of the season on Sept. 8, falling to Maryland 36-27 at home. The Owls are hoping to duplicate the success of their former MAC rivals Ohio, who beat PSU 24-14 in their season opener. Temple has not beaten Penn State since 1941.
There are some big games for Penn State's rivals in the Big Ten and Temple's new Big East rivals; including one other Big East vs. Big Ten game. Syracuse will head to Minnesota to take on the undefeated Golden Gophers. But the game of the week for the Big Ten will be No. 18 Michigan traveling to South Bend to take on No. 11 Notre Dame.
The full slate of Big Ten and Big East games for Week 4 is below, all times Eastern:
Temple Owls at Penn State Nittany Lions (3:30 p.m., ABC)
UAB at Ohio State (12:00 p.m., Big Ten Network)
UTEP at Wisconsin (12:00 p.m., ESPN2)
Central Michigan at Iowa (12:00 p.m., BTN)
South Dakota at Northwestern (3:30 p.m., BTN)
Eastern Michigan at Michigan State (3:30 p.m., BTN)
Idaho State at Nebraska (3:30 p.m., BTN)
Michigan at Notre Dame (7:30 p.m., NBC)
Louisiana Tech at Illinois (8:00 p.m., BTN)
Syracuse at Minnesota (8:00 p.m., BTN)
Connecticut at Western Michigan (2:00 p.m., ESPN3)
Gardner-Webb at Pittsburgh (3:30 p.m., ESPN3)
South Florida at Ball State (4:30 p.m., ESPN3)
Rutgers at Arkansas (7:00 p.m., ESPNU)
Louisville at Florida International (7:00 p.m., ESPN3)
For more on Penn State check out Black Shoe Diaries. For more on the Big Ten, check out Off Tackle Empire. For Big East news, head to Big East Coast Bias. And for all your NCAA football news, be sure to visit SB Nation's college football hub.