After trailing 30-28 at the half, an unflustered Lehigh squad put the clamps on the Blue Devils', holding Duke to just 23.1 percent from behind the arc.
Lehigh was led by C.J. McCollum who scored 30 points and pulled down seven rebounds. Gabe Knutson added 17 points to pave the way.
Mason Plumlee of Duke did his part, scoring 21 points while shooting a perfect 10-for-10 from the field, however Duke's guards failed to pick up the slack. Austin Rivers had 19 points but shot just 5-for-14 from the field in what was most likely his last game playing for the Blue Devils.
Lehigh will take on the winner of the Notre Dame-Xavier game later Friday night.
For more NCAA Tournament coverage, be sure to check out our tournament stream, SB Nation's tournament hub and SB Nation Philly. Also make sure to check out our NCAA Tournament Printable Bracket stream. Enjoy the road to New Orleans!